FIG 9.

COX-2 increases insulin signaling by downregulation of miR-183. PGE₂ stabilizes DDX5 expression through the PI3K/p300 signaling pathway. COX-2 associates with the Drosha complex through DDX5 and prevents the conversion of pri-miRNAs into pre-miRNAs. The association leads to a decrease of mature miR-183 levels and therefore to an increase in the level of its gene target, IRS1, a key protein in the insulin signaling pathway. DDX5, DEAD-box helicase p68; Drosha, RNase type III; DGCR8, DiGeorge syndrome critical region gene 8; m⁷G, 7-methylguanosine-cap.