Table 5.

Whole-Genome Scan of Quantitative Immune-System Phenotypes^[Note]

Chromosomeand Phenotype	Region(cM)	Empirical Pa	Nominal Pb
1:
Lymphocyte count	200–231	.0013	.0018
CD19	197–228	.0024	.0039
CD4	227–252	.0015	.0057
CD8	196–222	.00013	.00020
2:
Lymphocyte count	28–54	.0026	.019
CD19	50–56	.0010	.0039
CD4	24–40	.00028	.00078
CD4:CD8	89	.0013	.006
3:
NK	192–199	.0048	.019
4:
CD4:CD8	2–5	.0027	.012
CD4:CD8	53–79	.00007	.00012
8:
Lymphocyte count	15–18	.0064	.014
CD19	16–20	.0029	.0040
CD4	65–79	.00005	.0039
9:
CD4	74–84	.00083	.0022
11
Lymphocyte count	38–39	.0052	.012
12:
CD19	149–156	.00082	.011
18:
CD19	93–100	.0033	.0054
CD4	99–105	.0028	.0051

Note.— Probabilities were calculated using the SIBPAL2 W2 method.

^aEmpirical significance levels (for P<.01) by chromosome regions, calculated using multipoint “new Haseman-Elston” weighted regression method with both age and sex in the model (Haseman and Elston 1972; Xu et al. 2000; SAGE 2001c).

^bNominal significance levels, with both age and sex in the model.