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Multipoint variance-component linkage analysis of all 22 autosomes in pedigrees with early-onset COPD. Results of linkage analysis are presented for FEV1, FEV1/FVC, and FVC, with adjustment for relevant covariates. Genetic distance (in cM), from version 10 of the Marshfield map, is plotted against variance-component LOD score. Significant linkage was demonstrated for FEV1/FVC, on chromosome 2 (LOD score 4.12).
