Figure 1.

The effect of chaetocin and UNC0638 on human AML cell lines. (a) Expression of G9a and SUV39H1 in HL-60, U937 and KG-1a cells. The expression levels of HL-60 were defined as 1. (b) Cells were treated with high concentrations of UNC0638 (50–200 μm) or chaetocin (50–200 nm) for 24 h and cell viability was studied by MTT assay. (c) Cells were incubated with low concentrations of UNC0638 (0–25 μm) or chaetocin (0–100 nm) for 24 h. IC₅₀ values were determined for each cell line.