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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Shock. 2015 Mar;43(3):255–260. doi: 10.1097/SHK.0000000000000291

Figure 3. Degree of brain injury alters the maturation state of infiltrating monocyte-derived cells at 24 hours post injury.

Figure 3

A, The majority of peripheral leukocytes within the sham-injured brain are monocytes. B, After mild TBI, peripheral leukocytes infiltrate into the brain tissue with a significant increase in the number of early monocyte-derived (CD64+MHCII−) macrophages (MD-Mϕ) (p<0.02) as compared to sham injury. C, Severe TBI results in a marked increase in infiltrating leukocytes within the injury brain. Although monocytes and MD-Mϕ are still present in large numbers, the proportion of inflammatory (CD64−MHCII+) dendritic cells (iDC) increased substantially after severe TBI as compared to both sham injury (p<0.001) as well as mild TBI (p<0.002).