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Histopathologic features of CANDLE syndrome. A, Skin sections demonstrating a mixed interstitial and perivascular inflammatory infiltrate. B-D, Higher magnification of A, revealing abundant atypical myeloid cells combined with mature neutrophils, in addition to mature lymphocytes and some eosinophils. Leukocytoclasis is also present. H&E, Original magnifications, 10X (A), 20X (B), 40X (C), 100X (D).
