Table 1.
Haplotypes and Map Positions of Chromosome 18 Markers in Kindreds with JP
|
Alleles in Kindred from |
|||||||
| Marker | Iowa | Mississippi | Texas | Finland | Distancea(cM) | Distance fromSMAD4 Exon 1(kb) | Heterozygosity |
| D18S970 | 3 | 6 | 3 | 3 | 93.9 | … | .67b |
| D18S1099 | 4 | 3 | 3 | 3, 5c | 98.0 | … | .58d |
| D18S474 | 8 | 4 | 1 | 8, 10c | 98.0 | 121.2 | .82d |
| D18S1110 | 3 | 3 | 5 | 6 | 98.0 | 37.0 | .75d |
| SMAD4 exon 11 | 31.4 | … | |||||
| SMAD4AT/CA | 4 | 7 | 9 | 13 | 26.3 | .90 | |
| Deletion | 4 bp | 4 bp | 4 bp | 4 bp | 20.2 | … | |
| SMAD4GATA | 2 | 3 | 2, 3c | 3 | 50.7 | .55 | |
| D18S46 | 7 | 5 | 6 | 10 | <99.2e | 132.9 | .80d |
| GATA06 | 3 | 2 | 5 | 4 | 104.1 | … | .80b |
| D18S1156 | 3 | 2 | 2 | 2 | 104.1 | … | .54d |
| D18S851 | 3 | 2 | 5 | 4 | 105.5 | … | .55b |
| D18S484 | 1 | 1 | 3 | 3 | 105.5 | … | .72d |
| D18S539 | 3 | 2 | 5 | 4 | 105.5 | … | .63b |
| D18S487 | 5 | 5 | 6 | 6 | 106.3 | … | .81d |
| D18S846 | 2 | 2 | 2 | 2 | 107.5 | … | .38b |
| D18S977 | 1 | 4 | 4 | 4 | ∼110 | … | .92b |
a
Based on the Center for Medical Genetics sex-averaged map.
b
From the Cooperative Human Linkage Center.
c
The specific allele cosegregating with JP could not be determined.
d
From the Genome Database.
e
Map position of D18S363, which is 165.5 kb telomeric to D18S46 (see text).