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. 2015 Mar 11;32(7):1815–1832. doi: 10.1093/molbev/msv062

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© The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Formation of polyadenylated snRNA pseudogenes. The L1 RNP complex is constituted by ORF1p homotrimers (vertical ovals), ORF2p (horizontal oval), and L1 RNA (wavy line with poly(A) tail). Cleaved genomic DNA target is represented by interrupted black lines. (a) The polyadenylated snRNA is present in the nucleus and the L1 RNP complex formed in the cytoplasm enters the nucleus. (b) ORF2p dissociates from the L1 RNP complex and is then associated with the polyadenylated snRNA. (c) L1 RNP complex cleaves the target site (first step of TPRT). (d) Free nuclear ORF2p binds to polyadenylated snRNA. (e) The RNP formed by ORF2p and the polyadenylated snRNA from panel (b) or (d) initiates TPRT. (f) L1 RNA dissociates from the L1 RNP depicted in panel (c) at the target site, and polyadenylated snRNA is associated with the free ORF2p still present at the target site. (g) Resolution of the initiated TPRT from panel (e) or (f). In panel (g), arrowheads represent TSD.