Table 3.
Predictive factors for local control
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Parameters | Hazard ratio (95 % CI) | P value | Hazard ratio (95 % CI) | P value |
| Age (≤67/>67) years | 1.13 (0.49–2.78) | 0.772 | 1.01 (0.97–1.07) | 0.762 |
| Gender (male/female) | 0.75 (0.31–1.76) | 0.519 | 1.33 (0.46–3.95) | 0.585 |
| ECOG score (0–1/2) | 1.13 (0.48–2.84) | 0.778 | 1.73 (0.66–4.94) | 0.264 |
| Etiology (viral/non-viral) | 1.01 (0.79–1.27) | 0.959 | 2.17 (0.61–8.28) | 0.227 |
| Child-Pugh class (A/B) | 0.87 (0.74–0.96) | 0.003 | 0.85 (0.69–0.98) | 0.022 |
| AFP (≤400/>400) ng/ml | 0.83 (0.76–0.93) | <0.001 | 0.81 (0.74–0.93) | 0.011 |
| Albumin (>3.6/≤3.6) g/dL | 0.88 (0.71–0.91) | 0.049 | 1.26 (0.52–6.41) | 0.231 |
| Hemoglobin (>11/≤11) g/dL | 0.72 (0.64–0.88) | 0.044 | 1.41 (0.59–6.86) | 0.213 |
| PVTT (no/yes) | 2.36 (0.87–6.39) | 0.091 | 1.66 (0.68–5.12) | 0.121 |
| BED (>65.5/≤65.5) Gy10 | 0.78 (0.69–0.92) | 0.023 | 0.81 (0.71–0.93) | 0.032 |
| RT duration (≤37/>37) days | 1.07 (0.92–6.34) | 0.029 | 1.52 (0.41–5.24) | 0.512 |
PVTT portal vein tumor thrombus, HCC hepatocellular carcinoma, ECOG Eastern Cooperative Oncology Group, BED biologically effective dose, RT radiation therapy, AFP Alpha-fetoprotein