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The assembled NADPH oxidase, type 2 (NOX2) complex. gp91phox (NOX2) and p22phox are integral plasma membrane components and together constitute cytochrome b558. The remaining components are normally cytosolic proteins that translocate to the plasma membrane following their phosphorylation. that is generated by NOX2 is converted to H2O2, which can diffuse across the plasma membrane, possibly through aquaporin (AQP) channels, to initiate cell signaling.
