Extended Data Figure 6. CaMKII inhibitors block potentiation of task-related dendritic spines but not Ca²⁺ spike generation.

a, There is no correlation between the percentage change in the peak amplitude of spine Ca²⁺ transients and the peak amplitude of dendritic Ca²⁺ spike during forward running in the presence of CaMKII inhibitors (KN-62: P = 0.08; KN-93: P = 0.42, Pearson’s correlation). b, Two-photon images of apical tuft dendrites expressing GCaMP2.2c during quiet resting state and forward running in the presence of ACSF, KN-93 and KN-62. c, d, Local application of CaMKII inhibitors, KN-93 and KN-62, to layer 1 did not induce significant changes in Ca²⁺ spike frequency or peak amplitude as compared to ACSF controls (P> 0.05, unpaired t-test). Scale bar, 10 µm. Data are mean ± s.e.m. Extended Data