Figure 2. Genes identified by CHIP-Seq are involved in NF-kB activation in MDS CD34+ cells.

(a) Immuno-histochemical analysis of phospho-p65 in MDS (Top panel) and controls (Bottom panel) bone marrow CD34+ cells. (b) Knock-down of C5AR1, FPR2, TYROBP and PTAFR in OCI-AML3 cells. (c) Immuno-histochemical analysis of phospho-p65 in the OCI-AML3 cells after knock-down of the 4 genes described above (Left panel) in comparison to control siRNA transfected cells (Right panel).