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. Author manuscript; available in PMC: 2015 Jun 22.
Published in final edited form as: Leukemia. 2013 Mar 29;27(11):2177–2186. doi: 10.1038/leu.2013.91

Table 1. Genes identified by CHIP-Seq to associate with high H3K4me3 at promoters in MDS CD34+ cells.

GENE GENE BANK # CHR START END (HG18) TO TSS FUNCTION & ASSOCIATION WITH INNATE IMMUNE OR TLR SIGNALING
FCER1G NM_004106 1 159452113 159453525 403 γ chain receptor of IgE Fc fragment. Synergize with TLR to augment production of inflammatory cytokines(39)
GBP5 NM_052942 1 89510023 89510813 -1096
PTAFR NM_000952 1 28374310 28375848 -1468 Platelet activating factor receptor. Mediates recognition and intake of bacterial components (40)
S100A8 NM_002964 1 151629315 151630287 -858 S100 calcium binding protein A 8. A chemoattractant and endogenous ligand of TLR4 (41)
FCGR2A NM_021642 1 159743029 159743795 1186 γ chain of receptor of IgG Fc fragment adaptor (42)
S100A9 NM_002965 1 151596426 151598773 -527 S100 calcium binding protein A 9. A chemoattractant and endogenous ligand of TLR4 (41)
FGR NM_001042747 1 27823620 27824853 -1718 Src tyrosin kinase (43)
RGS18 NM_130782 1 190394360 190395631 146
NCF2 NM_000433 1 181824396 181826329 -1966 Neutrophil cytosolic factor 2. Component of NADPH oxidase essential for innate immune response (44)
CD244 NM_016382 1 159098292 159099253 -977 Natural killer cell receptor 2B4. Enhances proliferation of NK cell (45)
IL8RA NM_000634 2 218738864 218739249 -1097 CXCR1, IL-8 receptor 1 (46)
SLC11A1 NM_000578 2 218955150 218956435 155 Solute carrier family 11 ion transporter (47)
IL8RB NM_001557 2 218700385 218701692 1395 CXCR2, IL-8 receptor 2 (46)
LMCD1 NM_014583 3 8517975 8518710 -535
FYB NM_199335 5 39254434 39255528 -990 Adaptor protein for tyrosin kinase FYN. Promotes activation NF-kB (48)
GIMAP4 NM_018326 7 149895232 149896350 -158
CLDN15 NM_014343 7 100665881 100667890 -1955
FCN1 NM_002003 9 136948675 136949763 -955 Ficolin. Activates innate immunity via complement system (49)
TMEM203 NM_053045 9 139219681 139219933 -230
IFITM2 NM_006435 11 298793 299540 687 IFN-γ induced transmembrane protein 2. Mediates antiviral signal (50)
CLEC7A NM_022570 12 10172300 10172678 -1835 Dectin, C-type lectin receptor. Activates downstream signaling through Sky/ CARD9 (51)
AQP9 NM_020980 15 56219153 56219627 1454
BCL2A1 NM_004049 15 78049295 78050693 -1403 BCL2-related protein A (52)
ELMO3 NM_024712 16 65791023 65791506 495 Engulfment and cell motility protein 3 (53)
MEFV NM_000243 16 3245967 3246996 -661 Pyrin. Modulator of innate immunity (54)
C5AR1 NM_001736 19 52504812 52505462 -131 C5A receptor. Complement system signaling activator (55)
FPR1 NM_002029 19 56945476 56946459 -1486 N-formylpeptide chemoattractant receptor 1. G protein-coupled receptor (56)
FPR2 NM_001005738 19 56956243 56956574 -21 N-formylpeptide chemoattractant receptor 2. G protein-coupled receptor (56)
PRX NM_181882 19 45610885 45611447 -226
C19orf33 NM_033520 19 43486092 43486480 -551
FCAR NM_133277 19 60078907 60079291 1547 Receptor for IgA Fc fragment (57)
LRG1 NM_052972 19 4490259 4491216 -777
TYROBP NM_003332 19 41090039 41091378 -987 ITAM containing innate immunity signal mediator (58)
CFD NM_001928 19 811439 812250 775 Complement factor D, C3 convertase activator (59)
C20orf54 NM_033409 20 697002 697468 -226
CD93 NM_012072 20 23013407 23015099 -1570 Cell-surface glycoprotein and type I membrane protein. A receptor for C1q, can also be shedded and becoming a TLR ligand (60)