Table 1. Functional Categories of σ^E-Regulated Proteome^a.

Functional Categories	Total from	Total detected in proteome	Up-regulated by σE			Down-regulated by σE
			LB log	LPM 4h	LPM 20h	LB log	LPM 4h	LPM 20h
Amino acid biosynthesis	130	48	2	2	1	2	1	2
Biosynthesis of cofactors, prosthetic groups, and carriers	167	60	1			4	4	6
Cell envelope	479	82		1		7	8	4
Cellular processes	289	85	8	6	6	11	13	7
Central intermediary metabolism	170	61	2	6		4	6	4
DNA metabolism	166	32				1	4	3
Energy metabolism	610	216	8	4	4	15	31	16
Fatty acid and phospholipid metabolism	80	23		1		3	7
Hypothetical proteins	78	17	4	2			2	2
Mobile and extrachromosomal element functions	250	11				1	2	3
Protein fate	191	59		4		1	10	4
Protein synthesis	375	129	4	3		11	10	12
Purines, pyrimidines, nucleosides, and nucleotides	81	50	1		1	4	4
Regulatory functions	305	46	1	2	2	3	7	8
Signal transduction	26	5	1					1
Transcription	57	22				2	3
Transport and binding proteins	628	78	2	14	4	9	13	11
Unclassified	332	44	3	1	2	3	4	2
Unknown function	670	145	11	12	5	7	8	11

^aProteins regulated by σ^E are classified according to the JCVI (J. Craig Venter Institute), formerly TIGR (The Institute for Genomic Research), annotation system. Note that some proteins are annotated to multiple categories, accounting for the larger total gene count.