. Author manuscript; available in PMC: 2016 Apr 21.

Published in final edited form as: Ann Intern Med. 2015 Apr 21;162(8):533–541. doi: 10.7326/M14-1430

Table 4.

Hypothetical Relative Risk of Adverse Effects Required to Offset CVD Benefit under Base Case Assumptions

	LDL-C ≥ 4.91 mmol/L (190 mg/dL)	LDL-C ≥4.14 mmol/L (160 mg/dL)	LDL-C ≥ 3.36 mmol/L (130 mg/dL)	Diabetics	Treat All
Functional Limitation	1.24 (1.02, 1.41)	1.18 (0.79, 1.64)	1.15 (0.84, 1.42)	1.15 (1.02, 1.30)	1.10 (0.84, 1.34)
Mild Cognitive Impairment	1.29 (1.02, 1.48)	1.21 (0.75, 1.76)	1.17 (0.81, 1.50)	1.18 (1.02, 1.35)	1.12 (0.81, 1.41)

Abbreviations: LDL-C = low-density lipoprotein cholesterol