Table 2.
Summary statistics for biomarkers and psychosocial factors across time points. A GEE model was used separately for each variable to test for the effect of time.
| Biomarkers | Time 1a N = 18 Mean (SD) Median (min–max) |
Time 2a N = 14 Mean (SD) Median (min–max) |
Time 3a N = 14 Mean (SD) Median (min–max) |
p-valueb |
|---|---|---|---|---|
| TNF-α (pg/mL) | 9.0 (2.3) 8.8 (5.2–13.6) |
13.9 (6.3) 10.0 (7.6–23.0) |
13.9 (13.0) 9.1 (4.6–57.0) |
<0.01 |
| IL-6 (pg/mL) | 3.7 (3.9) 2.1 (1.0–14.8) |
9.5 (7.3) 8.5 (1.9–28.9) |
4.0 (4.5) 2.8 (1.0–18.2) |
<0.0001 |
| IL-8 (pg/mL) | 24.6 (35.1) 11.9 (5.4–134.4) |
14.7 (14.5) 9.1 (3.8–51.4) |
19.3 (16.9) 13.3 (2.6–62.6) |
0.15 |
| IL-10 (pg/mL) | 1.5 (1.7) 1.0 (0.5–7.4) |
11.3 (13.9) 2.4 (0.5–33.8) |
1.3 (0.9) 1.2 (0.5–4.0) |
<0.0001 |
| CRP (μg/mL) | 11.5 (11.7) 8.1 (0.1–38.1) |
66.7 (38.7) 62.7 (6.5–105.0) |
9.1 (9.9) 4.3 (0.2–33.1) |
<0.001 |
| VEGF (pg/mL) | 64.3 (31.5) 61.9 (15.7–141.4) |
51.4 (31.3) 43.3 (12.5–106.6) |
89.8 (61.5) 70.4 (23.9–272.0) |
<0.0001 |
| 2-AG (pmol/mL) | 152.5 (208.1) 98.4 (17.8–848.2) |
146.6 (169.0) 60.9 (32.1–549.6) |
116.1 (156.1) 59.1 (17.6–604.4) |
0.69 |
| AEA (pmol/mL) |
1.7 (1.0) 1.3 (0.8–5.0) |
1.4 (0.5) 1.5 (0.5–2.3) |
1.2 (0.6) 0.9 (0.6–3.1) |
0.18 |
| Psychosocial factors Mean (SD) |
N = 15 |
N = 10 |
N = 9 |
|
| CES-D | 9.3 (9.4) 6 (1–27) |
17.8 (13.6) 15 (3–42) |
5.6 (5.1) 5 (0–15) |
<0.01 |
| STAI-T | 39.0 (12.1) 35 (25–61) |
33.8 (11.4) 32.5 (22–60) |
31.9 (8.7) 29 (20–47) |
0.01 |
a
Time 1 = Before transplant (Day −1 – Day −8); Time 2 = Time of hospital discharge (Day +9 – Day +17); Time 3 = 100 days post-transplant (Day +91 – Day +175).
b
GEE-based test for equal mean at all time-points.