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Effects of late INa modulations and CaMKII inhibition on SR-Ca2+-leak in atrial CM of WT mice. (A) Surface plot of representative confocal line scans. (B–G) Mean values of CaSpF, Ca2+ spark amplitude, and the total calculated SR-Ca2+-leak in the presence of the respective drugs (B–D: n mice/cells = 6/122 vs. 6/123 vs. 6/108 vs. 6/119; E–G: n = 5/89 vs. 5/93 vs. 5/92). *significant vs. control; #significant vs. ATX-II. */#P < 0.05; **/##P < 0.01; ***/###P < 0.001.
