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. 2015 May 19;107(1):184–196. doi: 10.1093/cvr/cvv153

Figure 5.

Figure 5

Effects of late INa induction on cellular cAMP levels in atrial CMs of mice. (A–D) YFP/CFP tracings in CMs of EPAC-camps transgenic mice upon ATX-II (0.5 nmol/L) and subsequent isoproterenol treatment (100 nmol/L). CMs were preincubated with a (B) PDE inhibitor IBMX (100 µmol/L), (C) an inhibitor of AC 5/6 (NKY80, 10 µmol/L), (D) an inhibitor of reverse-mode NCX KBR (0.1 µmol/L), or (A) no inhibitor. (E) Quantification of response of YFP/CFP ratio (n mice/cells = 10/39 vs. 3/8 vs. 3/10 vs. 3/11). *significant vs. steady-state before ATX-II; #significant vs. YFP/CFP ratio upon ATX-II in the control group. */ #P < 0.05; **/##P < 0.01; ***/###P< 0.001.