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. 2015 May 19;107(1):184–196. doi: 10.1093/cvr/cvv153

Figure 7.

Figure 7

The impact of late INa modifications and CaMKII/PKA inhibition on stimulated and caffeine-induced Ca2+ transients of murine atrial CMs. (A) Representative original recordings (2 Hz, left) and caffeine-induced Ca2+ transients (right, arrow indicates caffeine application, WT). (B) Mean values of the amplitude (ΔF/F0) of stimulated Ca2+ transients (n mice/cells = 12/65 vs. 11/52 vs. 5/29 vs. 4/16 vs. 4/13 for B, D, E, and F). (C) Mean values of caffeine-induced Ca2+ transients (ΔF/F0; n = 10/42 vs. 11/37 vs. 5/27 vs. 4/15 vs. 4/13). (D) Mean values of Ca2+-transient amplitudes (ΔF/F0) at different stimulation frequencies. (E) Mean values of Ca2+-reuptake speed into the SR (ksys− kcaff). (F) Mean values of fractional Ca2+ release (FR, ΔF/F0 1 Hz/SR-Ca2+-load). (G) Representative original recordings of atrial CMs from CaMKIIδc-KO mice (arrow indicates caffeine application). (H) Mean values of caffeine-induced Ca2+ transients in CaMKIIδc-KO mice (n = 3/19 vs. 3/22; P < 0.05). *significant vs. control. */#P< 0.05; **/##P< 0.01; ***/###P< 0.001.