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. 2015 Apr 9;24(14):3918–3928. doi: 10.1093/hmg/ddv122

Figure 2.

Figure 2.

Intracellular retention of MT-COMP and chondrocyte death were decreased by treatment with aspirin or antioxidants. TUNEL and human COMP immunostaining of P28 growth plates from control (C57BL\6) and MT-COMP mice treated with aspirin, ibuprofen, resveratrol, GSE, turmeric or Coq10 from P0 to P28. TUNEL staining is present in only the hypertrophic zone of wild-type mice (C57BL\6) (H), in comparison, most chondrocytes are TUNEL positive in the MT-COMP growth plate (O). TUNEL staining is markedly decreased in MT-COMP chondrocytes with aspirin, ibuprofen, resveratrol, GSE, turmeric or CoQ10 treatment (P–U compared with O). Drug therapy does not change TUNEL staining in control chondrocytes (I–N compared with H). Growth plates from at least 8 mice were examined for each treatment. Bar = 100 µm.