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. 2015 Apr 9;24(14):3918–3928. doi: 10.1093/hmg/ddv122

Figure 3.

Figure 3.

Growth plate chondrocyte proliferation in MT-COMP mice was restored by treatment with aspirin or antioxidants. Proliferating cell nuclear antigen immunostaining of P28 growth plates from control (C57BL\6) and MT-COMP mice treated with aspirin or resveratrol from P0 to P28. Proliferating cell nuclear antigen staining is present throughout the wild-type growth plate (C57BL\6) (A), in comparison; less PCNA immunostaining is present in the MT-COMP growth plate (B). Proliferating cell nuclear antigen staining is markedly increased in MT-COMP chondrocytes with aspirin or resveratrol treatments (B compared with C and D). Growth plates from at least 8 mice were examined for each treatment. Bar = 100µm.