Figure 6.

Rescue of retinal function in Rpgr-KO mice that received 1 × 10⁹ vg AAV8-hRPGR vector treatment. Mice received unilateral injections of the vector and contralateral injections of vehicle at 6–8 weeks of age. (A) ERG analysis of vector-injected and vehicle-injected eyes at 12 months and 18 months PI. Although improvement in the vector-injected eyes was not obvious at 12 months PI, significantly larger amplitudes of dark-adapted a-, b-wave and light-adapted b-wave were observed in response to increasing intensities of flash stimuli at 18 months PI. (B) Comparisons between vector-injected and vehicle-injected eye in each individual animal for ERG amplitudes elicited from the highest flash intensity (n = 11). (C) Representative ERG wave forms from a single Rpgr-KO mouse at 18 months PI. Error bars show SEM, and the significance between the vector-injected and vehicle-injected eyes was calculated using two-tailed paired t-test. *P < 0.05; **P < 0.01; ***P < 0.001.