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. 2015 Apr 15;24(14):3982–3993. doi: 10.1093/hmg/ddv136

Figure 1.

Figure 1.

Brd4 is upregulated in cystic renal epithelial cells. (A–C) Western blot analysis of the expression of Brd4 protein in postnatal Pkd1 heterozygous PH2 (PH2) cells and Pkd1 homozygous PN24 (PN24) cells (A), in postnatal day 28 kidneys from Pkd1+/+ (WT) mice and Pkd1nl/nl (nl/nl) mice (B), and in postnatal day 14, 21 and 28 kidneys from Pkd1+/+:Pkhd1-Cre (WT) and Pkd1flox/flox:Pkhd1-Cre (Flox) mice (C), respectively. In A and B, the expression of Brd4 was quantified from three independent immunoblots and was presented as the relative expression level of Brd4 standardized to actin in the bottom panel. *P < 0.05. (D) The immunohistochemistry staining of Brd4 in the postnatal day 14, 21 and 28 kidneys from Pkd1+/+:Pkhd1-Cre and Pkd1flox/flox:Pkhd1-Cre mice, respectively. Scale bar, 50 µm.