FIG. 8.

Rank ordered (descending) plot of surface area normalized AUC in each airway surface facet integrated over time and tissue depth in human mouth following single puff of cigarette smoke containing (a) 94 ppm acrolein, (b) 1028 ppm acetaldehyde, and (c) 108 ppm formaldehyde using breathing patterns shown in Figure 2. The ‘hot–spots’ (shaded regions) were defined as the top 2.5% of AUCs for each airway compartment as described in the text. The overall compartment averaged AUC’s (dashed line) are shown for comparison.