FIG. 9.

Comparisons between LADDs determined in the rat at NOAEL for nasal toxicity (top dashed red line—olfactory epithelium; bottom dashed blue line—anterior respiratory epithelium) in subchronic inhalation bioassays and LADD’s determined in the human for each epithelial tissue compartment of the conducting airways after smoking 10, 20, or 40 cigarettes/day (bars) for (a) acrolein, (b) acetaldehyde, and (c) formaldehyde in humans at representative cigarette yields (Table 3). LADD’s were calculated from the highest 2.5% of each airway compartment surface facet AUC (concentrations integrated over time, depth and normalized by facet surface area) during the final breath (rat) or puff inhalation (human) as shown in Figures 7 and 8 and described in the text.