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. 2015 Apr 13;146(1):89–100. doi: 10.1093/toxsci/kfv072

FIG. 2.

FIG. 2.

Inhaled 1400  W mitigates phosgene-induced lung injury, while there is no beneficial effect after systemic 1400 W delivery. Mice were exposed to filtered air or phosgene, with administration of systemic 1400 W or vehicle (PBS) (A, C) or inhaled 1400 W or vehicle (PBS) (B, D), and harvested 24 h after exposure. The level of protein in BAL fluid (upper panel) and total BAL cell number (middle panel) were analyzed (n = 5; mean ± SEM, P-value * < 0.05). Mice exposed to filtered air (E) versus phosgene+aerosolized vehicle (F) versus phosgene + aerosolized 1400 W (G) were analyzed for histological signs of lung injury (scale bar corresponds to 50 µm).