FIG. 1.

Classification of PAH and PAH mixture carcinogenic potential based on tumor incidence. Exposure of female FVB/N mice to PAHs following a 2-stage initiation/promotion skin tumor protocol resulted in (A) tumor incidence profiles of DBC >>> BaP= Mix2= Mix3 >> Mix1 = Control, based on statistical significance (***P < .0001, *P < .05 by 1-way ANOVA with Newman–Keuls multiple testing correction). Tumor incidence was calculated as the percent incidence for each treatment based on tumor type. B, Based on this ranking, PAH treatments were categorized as having low, moderate, or high carcinogenic potential in mouse skin.