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. 2015 Apr 22;146(1):135–145. doi: 10.1093/toxsci/kfv080

FIG. 3.

FIG. 3.

Pathways significantly enriched (P < .05) in skin postinitiation by PAH and PAH mixtures. Functional enrichment analysis was performed in MetaCore (GeneGO, Thomson Reuters) based on mappings of the significant (P < .05) genes in each treatment group onto built-in functional network processes and Gene Ontology biological process categories. Statistical significance for enrichment was calculated using a hypergeometric distribution. All processes included more than 15 genes. Gene Ontology biological processes were further filtered to include only the top 10 most significant (P < 5E−7) processes for each treatment group that were categorized greater than level 2 in the Gene Ontology tree.