Table 3. Description of Primary Osteosarcoma Incidence by Selected Characteristics, United States, 1999-2008.
| Appendicular (C40) | Axial (C41) | Total | ||||
|---|---|---|---|---|---|---|
| Count* (%) | Rate† (95% CI)‡ | Count (%) | Rate (95% CI) | Count (%) | Rate (95% CI) | |
| Total | 5, 379 (100.0%) | 2.06 (2.01, 2.12) | 1,725 (100.0%) | 0.65 (0.62, 0.69) | 7,104 (100.0%) | 2.71 (2.65, 2.78) |
| Age at diagnosis, years | ||||||
| 00-09 | 526 (9.8%) | 1.48 (1.36, 1.61) | 40 (2.3%) | 0.11 (0.08, 0.15) | 566 (8.0%) | 1.59 (1.46, 1.73) |
| 10-19 | 2,655 (49.4%) | 7.08 (6.81, 7.35) | 316 (18.3%) | 0.84 (0.75, 0.94) | 2,971 (41.8%) | 7.92 (7.64, 8.21) |
| 20-29 | 780 (14.5%) | 2.16 (2.01, 2.31) | 261 (15.1%) | 0.72 (0.64, 0.82) | 1,041 (14.7%) | 2.88 (2.71, 3.06) |
| 30-39 | 403 (7.5%) | 1.07 (0.97, 1.18) | 198 (11.5%) | 0.53 (0.46, 0.61) | 601 (8.5%) | 1.60 (1.47, 1.73) |
| 40-49 | 342 (6.4%) | 0.86 (0.77, 0.95) | 269 (15.6%) | 0.68 (0.60, 0.76) | 611 (8.6%) | 1.54 (1.42, 1.66) |
| 50-59 | 249 (4.6%) | 0.78 (0.69, 0.89) | 199 (11.5%) | 0.63 (0.54, 0.72) | 448 (6.3%) | 1.41 (1.28, 1.55) |
| 60-69 | 187 (3.5%) | 0.93 (0.80, 1.07) | 173 (10.0%) | 0.87 (0.74, 1.01) | 360 (5.1%) | 1.80 (1.61, 1.99) |
| 70-79 | 142 (2.6%) | 0.97 (0.82, 1.15) | 161 (9.3%) | 1.10 (0.94, 1.29) | 303 (4.3%) | 2.08 (1.85, 2.32) |
| 80+ | 95 (1.8%) | 1.03 (0.83, 1.26) | 108 (6.3%) | 1.17 (0.96, 1.41) | 203 (2.9%) | 2.20 (1.91, 2.53) |
| Gender | ||||||
| Male | 3,057 (56.8%) | 2.32 (2.24, 2.41) | 885 (51.3%) | 0.70 (0.65, 0.74) | 3,942 (55.5%) | 3.02 (2.93, 3.12) |
| Female | 2,322 (43.2%) | 1.79 (1.72, 1.87) | 840 (48.7%) | 0.62 (0.58, 0.66) | 3,162 (44.5%) | 2.41 (2.33, 2.50) |
| Race§ | ||||||
| White | 4,176 (77.6%) | 1.99 (1.93, 2.05) | 1,387 (80.4%) | 0.64 (0.60, 0.67) | 5,563 (78.3%) | 2.63 (2.56, 2.70) |
| Black | 856 (15.9%) | 2.42 (2.26, 2.59) | 252 (14.6%) | 0.81 (0.71, 0.92) | 1,108 (15.6%) | 3.23 (3.03, 3.43) |
| AI/AN | # | 1.34 (0.97, 1.83) | # | # | 54 (0.8%) | 1.87 (1.36, 2.51) |
| API | 220 (4.1%) | 1.75 (1.52, 2.00) | 53 (3.1%) | 0.45 (0.33, 0.59) | 273 (3.8%) | 2.19 (1.94, 2.48) |
| Ethnicity∥ | ||||||
| Hispanic | 1,037 (19.3%) | 2.37 (2.22, 2.54). | 222 (12.9%) | 0.64 (0.55, 0.74) | 1,259 (17.7%) | 3.01 (2.83, 3.20) |
| Non-Hispanic | 4,342 (80.7%) | 2.00 (1.94, 2.06) | 1,503 (87.1%) | 0.66 (0.62, 0.69) | 5,845 (82.3%) | 2.66 (2.59, 2.73) |
| Region | ||||||
| Northeast | 1,085 (20.2%) | 2.06 (1.94, 2.19) | 384 (22.3%) | 0.70 (0.63, 0.77) | 1,469 (20.7%) | 2.76 (2.62, 2.90) |
| Midwest | 1,310 (24.4%) | 2.03 (1.92, 2.14) | 417 (24.2%) | 0.64 (0.58, 0.70) | 1,727 (24.3%) | 2.67 (2.54, 2.79) |
| South | 1,571 (29.2%) | 2.05 (1.95, 2.15) | 545 (31.6%) | 0.70 (0.65, 0.77) | 2,116 (29.8%) | 2.75 (2.64, 2.87) |
| West | 1,413 (26.3%) | 2.10 (1.99, 2.21) | 379 (22.0%) | 0.57 (0.52, 0.64) | 1,792 (25.2%) | 2.68 (2.55, 2.80) |
| Grade | ||||||
| I | 220 (4.1%) | 0.08 (0.07, 0.09) | 95 (5.5%) | 0.04 (0.03, 0.04) | 315 (4.4%) | 0.12 (0.11, 0.13) |
| II | 261 (4.9%) | 0.10 (0.09, 0.11) | 153 (8.9%) | 0.06 (0.05, 0.07) | 414 (5.8%) | 0.16 (0.14, 0.17) |
| III | 1,350 (25.1%) | 0.52 (0.49, 0.54) | 462 (26.8%) | 0.17 (0.16, 0.19) | 1,812 (25.5%) | 0.69 (0.66, 0.72) |
| IV | 2,012 (37.4%) | 0.77 (0.74, 0.81) | 439 (25.4%) | 0.17 (0.15, 0.18) | 2,451 (34.5%) | 0.94 (0.90, 0.98) |
| Unknown | 1,536 (28.6%) | 0.59 (0.56, 0.62) | 576 (33.4%) | 0.22 (0.20, 0.24) | 2,112 (29.7%) | 0.81 (0.78, 0.85) |
| Stage at diagnosis¶ | ||||||
| In situ | 0 (0.0%) | 0.00 (0.00, 0.00) | 0 (0.0%) | 0.00 (0.00, 0.00) | 0 (0.0%) | 0.00 (0.00, 0.00) |
| Localized | 2,181 (40.5%) | 0.84 (0.80, 0.87) | 472 (27.4%) | 0.18 (0.16, 0.20) | 2,653 (37.3%) | 1.01 (0.98, 1.05) |
| Regional | 1,837 (34.2%) | 0.70 (0.67, 0.74) | 630 (36.5%) | 0.24 (0.22, 0.26) | 2,467 (34.7%) | 0.94 (0.91, 0.98) |
| Distant | 938 (17.4%) | 0.36 (0.34, 0.38) | 393 (22.8%) | 0.15 (0.13, 0.16) | 1,331 (18.7%) | 0.51 (0.48, 0.54) |
| Unstaged | 423 (7.9%) | 0.16 (0.15, 0.18) | 230 (13.3%) | 0.09 (0.08, 0.10) | 653 (9.2%) | 0.25 (0.23, 0.27) |
Counts pertain to 90.1% of U.S population covered by eligible cancer registries. Data from 7 central cancer registries are not included.
Rates are per 1,000,000 persons and age-adjusted to the 2000 US standard population (19 age groups - Census P25-1130) except age-specific rates which were not age-adjusted.
95% CI indicates 95% confidence interval and were calculated using the Tiwari modification.
Other unspecified/unknown race accounted for 106 (1.5%) cases of primary osteosarcomas.
Race and ethnicity are not mutually exclusive.
SEER summary stage 1977 was used for 1999–2000 cases, SEER summary stage 2000 was used for 2001–2003 cases, and derived summary stage 2000 [also known as collaborative stage) was used for 2004–2008 cases.
Not presented due to count or rate instability or complementarity suppressed for confidentiality.
AI/AN, American Indian/Alaska Native; API, Asian/Pacific Islander; SEER, National Cancer Institute’s Surveillance, Epidemiology, and End Results Program.
Percentages may not add to 100% because of rounding. The analyses were limited to microscopically confirmed osteosarcomas.