Table 1.
Study Subjects
| Underlying Cause of Non–Cystic Fibrosis Bronchiectasis | Patient ID | Age (yr) | Sex (M/F) | HLA-Cw | HLA-DR | Percentage of Sputum Samples Culture Positive for Pseudomonas aeruginosa (0%, <50%, ≥50%) | Other Pathogens Isolated in Sputum | ||
|---|---|---|---|---|---|---|---|---|---|
| PCD | B01 | 57 | F | 6 | 7 | 11 | 15 | 0% | Haemophilus influenzae, Streptococcus pneumoniae |
| CVID | B03 | 66 | F | 7 | 8 | 1 | 17 | 0% | H. influenzae, S. pneumoniae, Moraxellacatarrhalis |
| Postinfective | B10 | 71 | F | 10 | 16 | 4 | 7 | 0% | URT flora, Staphylococcus aureus |
| Idiopathic | B09 | 62 | F | 7 | 7 | 15 | 17 | 0% | — |
| Postinfective | B18 | 76 | M | 6 | 10 | 13 | 14 | 0% | — |
| Idiopathic | B19 | 40 | M | 1 | 4 | 4 | 12 | 0% | — |
| Idiopathic | B25 | 75 | M | 4 | 7 | 1 | 1 | 0% | — |
| Idiopathic | B26 | 77 | F | 12 | 14 | 4 | 10 | 0% | URT flora |
| Idiopathic | B28 | 64 | F | 5 | 7 | 17 | 4 | 0% | URT flora |
| Postinfective | B29 | 31 | F | 4 | 15 | 14 | 15 | 0% | — |
| Idiopathic | B33 | 42 | M | 5 | 7 | 4 | 13 | 0% | URT flora |
| PCD | B35 | 40 | F | 7 | 7 | 1 | 15 | 0% | S. aureus |
| PCD | B36 | 59 | F | 9 | 7 | 11 | 13 | 0% | URT flora, Stenotrophomonasmaltophilia |
| PCD | B38 | 22 | F | 6 | 12 | 17 | 11 | 0% | H. influenzae, S. pneumoniae, M. catarrhalis, S. aureus |
| Postinfective | B39 | 51 | F | 4 | 5 | 1 | 14 | 0% | URT flora, S. aureus |
| Youngs | B45 | 59 | M | 1 | 4 | 4 | 15 | 0% | H. influenzae |
| Postinfective | B46 | 29 | F | 8 | 10 | 4 | 7 | 0% | S. pneumoniae |
| ABPA | B27 | 56 | F | 10 | 6 | 17 | 13 | 0% | URT flora, Aspergillus fumigatus |
| ABPA | B55 | 60 | M | 10 | 10 | 7 | 15 | 0% | URT flora |
| CVID | B56 | 41 | F | 1 | 5 | 1 | 11 | 0% | URT flora, H. influenzae |
| Postinfective | B54 | 59 | F | 6 | 10 | 7 | 13 | 0% | URT flora, H. influenzae |
| ABPA | B63 | 27 | F | 7 | 7 | 4 | 11 | 0% | URT flora, S. aureus |
| Idiopathic | B77 | 64 | M | 7 | 12 | 15 | 17 | 0% | URT flora, M. catarrhalis |
| PCD | B79 | 33 | F | 2 | 12 | 4 | 13 | 0% | URT flora, M. catarrhalis, H. influenzae |
| Idiopathic | B83 | 55 | M | 5 | 7 | 7 | 15 | 0% | URT flora |
| Postinfective | B73 | 60 | M | 7 | 7 | 4 | 15 | 0% | URT flora, S. pneumoniae, coliform |
| Youngs | B64 | 62 | F | 5 | 7 | 15 | 17 | 0% | URT flora, Candida albicans |
| PCD | B72 | 29 | F | 7 | 16 | 11 | 15 | 0% | URT flora, S. aureus, S pneumoniae |
| Idiopathic | B74 | 61 | F | 7 | 7 | 4 | 15 | 0% | URT flora, S. aureus |
| Postinfective | B75 | 64 | F | 7 | 6 | 1 | 15 | 0% | URT flora, H. influenzae |
| Postinfective | B62 | 53 | F | 7 | 7 | 15 | 15 | 0% | H. influenzae |
| ABPA | B12 | 67 | M | 4 | 7 | 1 | 14 | <50% | S. aureus |
| 3/7 nonmucoid | |||||||||
| Postinfective | B17 | 72 | F | 1 | 7 | 1 | 15 | <50% | URT flora |
| 1/6 nonmucoid | |||||||||
| Idiopathic | B31 | 72 | F | 7 | 14 | 1 | 17 | <50% | URT flora, Proteus vulgaris |
| 2/6 mucoid | |||||||||
| Idiopathic | B43 | 61 | F | 1 | 12 | 1 | 12 | <50% | URT flora |
| 3/8 mucoid | |||||||||
| Postinfective | B48 | 81 | F | 10 | 15 | 4 | 9 | <50% | URT flora |
| 1/6 nonmucoid | |||||||||
| Idiopathic | B50 | 64 | F | 7 | 5 | 7 | 15 | <50% | URT flora, M. catarrhalis, S. maltophilia |
| 1/7 nonmucoid | |||||||||
| Idiopathic | B52 | 52 | F | 7 | 7 | 1 | 7 | <50% | URT flora, coliform, S. maltophilia, S. aureus |
| 1/9 nonmucoid | |||||||||
| Idiopathic | B76 | 67 | F | 7 | 8 | 1 | 17 | <50% | URT flora, β-hemolytic Streptococcus group C |
| 1/9 nonmucoid | |||||||||
| Postinfective | B78 | 72 | F | 1 | 1 | 8 | 14 | <50% | URT flora, C. albicans |
| 2/7 mucoid | |||||||||
| Postinfective | B81 | 63 | F | 7 | 9 | 17 | 7 | <50% | URT flora, H. influenzae, S. aureus |
| 2/7 nonmucoid | |||||||||
| PCD | B68 | 53 | F | 4 | 12 | 15 | 4 | <50% | URT flora |
| 3/8 nonmucoid | |||||||||
| Postinfective | B71 | 68 | F | 2 | 14 | 1 | 4 | <50% | S. aureus |
| 1/7 mucoid | |||||||||
| Idiopathic | B02 | 78 | F | 2 | 7 | 4 | 17 | ≥50% | M. catarrhalis |
| 4/8 mucoid | |||||||||
| Postinfective | B13 | 70 | M | 6 | 12 | 11 | 14 | ≥50% | — |
| 7/7 mucoid | |||||||||
| Postinfective | B14 | 65 | M | 14 | 16 | 7 | 9 | ≥50% | — |
| 7/7 mucoid | |||||||||
| ABPA | B16 | 64 | M | 7 | 10 | 1 | 7 | ≥50% | S. aureus, H. influenzae |
| 5/7 mucoid | |||||||||
| Postinfective | B21 | 62 | F | 9 | 7 | 7 | 15 | ≥50% | — |
| 7/7 mucoid | |||||||||
| PCD | B23 | 30 | M | 7 | 7 | 4 | 15 | ≥50% | — |
| 1/1 mucoid | |||||||||
| ABPA | B40 | 64 | M | 4 | 7 | 1 | 13 | ≥50% | C. albicans |
| 5/7 mucoid | |||||||||
| Postinfective | B47 | 72 | F | 7 | 8 | 4 | 14 | ≥50% | — |
| 4/4 nonmucoid | |||||||||
| Idiopathic | B57 | 76 | F | 4 | 12 | 4 | 15 | ≥50% | — |
| 4/7 mucoid | |||||||||
| ABPA | B82 | 60 | M | 7 | 12 | 13 | 17 | ≥50% | — |
| 6/7 mucoid | |||||||||
| Postinfective | B67 | 66 | F | 17 | 4 | 1 | 7 | ≥50% | URT flora, A. fumigatus |
| 4/7 nonmucoid | |||||||||
| ABPA | B70 | 55 | F | 5 | 7 | 4 | 15 | ≥50% | — |
| 7/7 mucoid | |||||||||
| Idiopathic | B61 | 57 | F | 7 | 12 | 1 | 15 | ≥50% | URT flora |
| 5/7 mucoid | |||||||||
| PCD | B85 | 39 | F | 7 | 10 | 4 | 15 | ≥50% | |
| 6/6 nonmucoid | |||||||||
Definition of abbreviations: ABPA = allergic bronchopulmonary aspergillosis; CVID = common variable immunodeficiency; HLA = human leukocyte antigen; ID = identification; PCD = primary ciliary dyskinesia; URT = upper respiratory tract.
Sputum samples were collected monthly for 6 months and analyzed by microscopy and culture using standard microbiology techniques. Patients were divided into three groups defined by the percentage of sputum cultures collected that were positive for P. aeruginosa (0%, <50%, and ≥50%). The column also shows the number of sputum samples positive for mucoid isolates over the total number of sputum samples collected and analyzed. Where no mucoid P. aeruginosa was isolated, the number of sputum samples positive for nonmucoid isolates is given over the total number of sputum samples collected.