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. 2015 Jun 15;191(12):1432–1442. doi: 10.1164/rccm.201412-2148OC

Figure 7.

Figure 7.

The effect of a microRNA (miRNA)-96 mimic on hypoxia-induced pulmonary hypertension in female mice. (A) The effect of a 30-μg dose (intravenous) of miRNA-96 (miR-96) mimic on miRNA-96 expression in pulmonary artery (n = 5). (B) Representative images of miRNA-96 in situ hybridization in pulmonary arteries from hypoxic mice (scale bars = 40 μm). Effects of a miRNA-96 mimic 30-μg dose on (C) right ventricular systolic pressure (RVSP; n = 9–10), (D) right ventricular hypertrophy (RVH; n = 10), and (E) percentage of remodeled pulmonary arteries (n = 6) in normoxic and hypoxic female mice. (F) Representative images of pulmonary arteries (Elastin Van Giesen stain; scale bars = 50 μm). Data displayed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, determined by unpaired t test and one-way ANOVA with Tukey’s post hoc test. LV+S = left ventricle plus septum; RQ = relative quantity; RV = right ventricle; U6 = small nuclear RNA U6.