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. 2015 Jun 22;10(6):e0131266. doi: 10.1371/journal.pone.0131266

Fig 7. Downregulation of PS1 expression alters β-catenin metabolism and disrupts CREB expression.

Fig 7

A. Schematics of neurogenic signals that interact with PS1. B. Confocal image (Zeiss LSM 510) representing colocalization of pCREB and Nestin in the dentate gyrus of the hippocampus (40x). C, D. (i) Expression of total β-Catenin were similar in both groups. However, levels of phospho-β-Catenin (ii) were significantly decreased in neural progenitor cells with reduced PS1 expression. Levels of total GSK3β (iii), phospho-GSK3β (iv) and CREB (v) were similar in both groups. Phospho-CREB (vi) shows decreasing trend, albeit statistically not significant. Western blot analysis significance was determined by unpaired t-test with Welch’s correction, *P<0.05, **P<0.01. Error bars indicate ±SEM.