Table 2.

Frequencies of Pharmacogenetic Markers in Ethnic/Racial Populations

Medication	Pharmacogenetic Marker (Gene-Polymorphism: Genotype)	African	Caucasian	East Asian	South Asian
Naltrexone	OPRM1-rs1799971:GG/GA	0.023	0.292	0.622	0.693
Ondansetron	HTR3A-rs1150226:AG	0.470	0.134	Fixed	0.023
	HTR3A-rs1176713:GG	0.113	0.088	0.048	0.136
	HTR3B-rs17614942:AC	0.077	0.097	Fixed	0.023
	SLC6A4-5HTTLPR:LL	0.582†	0.334††	0.109‡	0.191‡‡
	SLC6A4-rs1042173:TT	0.736	0.283	0.042	0.216
Topiramate	GRIK1-rs2832407:CC	0.019	0.354	0.205	0.273

All frequency data are from HapMap, unless specified otherwise. Highest population frequencies are in boldface letters.

^†Douglas et al. 2011; Gelernter et al. 1998; Herman et al. 2011; Kraft et al. 2007; Roy et al. 2007.

^††Biederman et al. 2009; Douglas et al. 2011; Foley et al. 2004; Frisch et al. 1999; Geijer et al. 2000; Gerra et al. 2005; Gonda et al. 2010; Gokturk et al. 2008; Grabe et al. 2012a,b; Hallikainen et al. 1999; Herman et al. 2011; Illi et al. 2011; Iordanidou et al. 2010; Kronenberg et al. 2008; Landaas et al. 2010; Merenakk et al. 2011; Michaelovsky et al. 1999; Minelli et al. 2011; Mrazek et al. 2009; Mujakovic et al. 2011; Noskova et al. 2008; Pivac et al. 2009; Polito et al. 2011; Stoltenberg et al. 2012; van der Zwaluw et al. 2010; Volf et al. 2009.

^‡Choi et al. 2006; Chong et al. 2000; Chu et al. 2009; Gelernter et al. 1997; Hong et al. 2003; Katsuyama et al. 2008; Kim et al. 2006, 2007; Kweon et al. 2005; Li et al. 2007; Matsushita et al. 2001; Narita et al. 2001; Shin et al. 2010; Yamakawa et al. 2005; Yu et al. 2002.

^‡‡Banerjee et al. 2006; Guhathakurta et al. 2006; Vijayan et al. 2009, Kumar et al. 2007, 2012; Margoob et al. 2008; Sikander et al. 2009, Tibrewal et al. 2010.