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. 2015 Jun 22;10(6):e0131175. doi: 10.1371/journal.pone.0131175

Fig 5. Protection against M.tb challenge in mice immunized with BCG alone or primed with BCG and boosted with AdHu5Ag85A.

Fig 5

Infant and adult mice were BCG immunized, and boosted with AdHu5Ag85A i.n. at 16 weeks post-BCG (BCG/AdHu5Ag85A) (A). The control group was not boosted (BCG). The mice were then challenged i.n. 4 weeks after boosting with M.tb H37Rv. Bacterial burden in the lungs was assessed at 4 weeks post-challenge by a cfu assay with lung homogenates, expressed as log10 cfu per lung (B). Histopathological changes were examined by H&E staining of the lungs (C). Magnification: 5x. Results are from one experiment, n = 5/group. Data are expressed as Mean ± SEM. *, p < 0.05; **, p < 0.005.