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. 2015 Jun 22;10(6):e0130993. doi: 10.1371/journal.pone.0130993

Table 3. Crude mortality incidence rate ratio among the vascular dementia and non-vascular dementia groups.

Variables Vascular dementia (n = 2,142) Degenerative dementia (n = 10,051)
No medication Nootropics No medication Nootropics Anti-dementia medication Both medications
(n = 750, 35.0%)) (n = 1,392, 65.0%) (n = 4,130, 41.1%) (n = 4,850, 48.3%) (n = 240, 2.4%) (n = 831, 8.3%)
Age (mean ± SD) 78.8 ± 6.8 77.9 ± 6.7 80.5 ± 7.4 78.8 ± 6.9 78.4 ± 6.3 76.7 ± 6.2
Charlson comorbidity index (CCI) 2.29 ± 2.49 2.52 ± 2.58 1.77 .77.58 1.93 .93.58 1.38 ±.38 5 1.60 ±.60 5
CCI except dementia 2.01 ± 2.34 2.20 ± 2.42 1.62 .62424 1.76 .76424 1.14 ±.1495 1.30 ±.30 5
Prescription cumulative days (IQR)
    Nootropics 0 210 (63–577) 0 140 (44–420) 0.00 175 (58–511)
    Anti-dementia medication 0 0 0 0 308 (90–739) 336 (126–805)
Median follow-up, years (IQR) 2.04 (0.86–3.80) 3.66 (1.91–6.03) 1.79 (0.68–3.62) 3.25 (1.57–5.41) 3.04 (1.50–5.11) 4.13 (2.35–6.37)
Person-years at risk 2,009 5,746 10,333 18,118 853 3729
Death 415 593 2,321 2,077 64 218
Mortality incidence (/1000 py) 207 103 225 115 75 58
Crude IRR (ref: non-dementia) (95% CI) 2.82 (2.54–3.12) 1.41 (1.29–1.54) 3.07 (2.91–3.23) 1.56 (1.48–1.65) 1.02 (0.79–1.31) 0.80 (0.69–0.91)

SD: standard deviation; IQR: interquartile range; py: person-year; IRR: incidence rate ratio; CI: confidence interval