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. Author manuscript; available in PMC: 2015 Jun 22.
Published in final edited form as: Biotechnol Bioeng. 2013 Nov 30;111(4):829–841. doi: 10.1002/bit.25145

Figure 5.

Figure 5

a: Glycosaminoglycan contents of rBMSC-seeded scaffolds at different time points. The values at week 0 indicate 24 h after cell seeding (measured only for three scaffold types: PLGA, CS, and BG). Values are reported as mean ± standard deviation (n = 3–4), P < 0.05. *Statistically significant difference from all other groups; however, there was no significant difference between CS and TGF-CS at any given time point, **statistically significant difference from groups PLGA and the growth factor loaded constructs at week 6 and ^statistically significant difference from week 6 within a group. b: HYP (hydroxyproline) contents in rBMSC-seeded scaffolds at different time points. The BMP-BG constructs showed significantly higher values than the other groups at week 3; however, a significant decrease was observed at week 6 in contrast, multiple groups saw a drastic increase from week 3 to week 6. *Statistically significant difference from all other groups at week 3, #statistically significant difference from PLGA, TGF, and BMP-BG at week 6 and ^statistically significant difference from previous week. c: Calcium contents in rBMSC-seeded scaffolds at different time points. The PLGA-BG constructs showed significantly higher values than all other groups at week 3. *Statistically significant difference from all other groups at week 3, #statistically significant difference from PLGA at week 3, **statistically significant difference from all groups except PLGA and GRADIENT at week 6, @statistically significant from 6-week time point. PLGA poly(d,l-lactic-co-glycolic acid), CS (chondroitin sulfate), BG (bioactive glass), TGF-CS (transforming growth factor-chondroitin sulfate), and BMP-BG (bone morphogenic protein-bioactive glass).