Table 3. Association of arginine derivatives with the presence of atherosclerotic plaques.

		OR (95%-CI) for presence of atherosclerotic plaque
		Unadjusted	P	Fully adjusted	P
ADMA
	cont.*	4.38 (2.06; 9.16)	< 0.01	1.69 (0.72; 4.01)	0.23
	categorized, ref: 33rd- 66th
	< 33rd	1.10 (0.87; 1.40)	0.41	1.11 (0.85; 1.45)	0.45
	> 66th	1.25 (0.99; 1.58)	0.07	1.21 (0.92; 1.58)	0.17
SDMA
	cont. *	7.80 (3.30; 18.41)	< 0.01	0.93 (0.31; 2.74)	0.89
	categorized, ref: 33rd- 66th
	< 33rd	1.07 (0.84; 1.36)	0.59	1.05 (0.80; 1.38)	0.74
	> 66th	0.93 (0.74; 1.17)	0.54	0.94 (0.72; 1.26)	0.66
ARG
	cont. *	1.00 (0.99; 1.00)	0.58	1.00 (0.99; 1.00)	0.30
	categorized, ref: 33rd- 66th
	< 33rd	1.09 (0.86; 1.37)	0.50	1.15 (0.87; 1.51)	0.51
	> 66th	1.31 (1.03; 1.66)	0.03	1.41 (1.07; 1.85)	0.01
DMA
	cont. *	3.14 (1.98; 4.97)	< 0.01	1.21 (0.70: 2.09)	0.50
	Categorized, ref: 33rd- 66th
	< 33rd	0.99 (0.78; 1.25)	0.90	1.00 (0.76; 1.32)	0.99
	> 66th	0.98 (0.77; 1.24)	0.85	0.97 (0.74; 1.28)	0.85
ARG/ADMA ratio
	cont. *	0.99 (0.99; 1.00)	0.09	1.00 (0.99; 1.00)	0.86
	Categorized, ref: 33rd- 66th
	< 33rd	0.95 (0.75; 1.21)	0.69	0.96 (0.73; 1.27)	0.57
	> 66th	0.97 (0.76; 1.23)	0.78	1.01 (0.77; 1.33)	0.67

OR = odds ratio, CI = confidence interval, adjusted for age, sex, smoking, WHR, and GFR.

*OR for a 1 unit increase in serum ARG derivative concentration or ARG/ADMA ratio. cIMT indicates carotid intima-media thickness; WHR, waist-to-hip ratio; eGFR, estimated-glomerular-filtration-rate; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; ARG, ˪-Arginine; DMA, dimethylarginine; ARG/ADMA, Arginine-asymmetrical dimethylarginine ratio.