Table 1. Characteristics of BBD cases/controls and risk/protective factors.
| FA | FAC | FCC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NegativeNum. (%) | PositiveNum. (%) | P-value | Negative Num. (%) | Positive Num. (%) | P-value | Negative Num. (%) | Positive Num.(%) | P-value | ||
| Total 1 | 1262(100) | 308(100) | 1427(100) | 143(100) | 695(100) | 875(100) | ||||
| Age | <41 | 261(21) | 171(56) | < .0001 | 409(29) | 23(16) | 0.002 | 264(38) | 168(19) | < .0001 |
| [41,60] | 621(49) | 107(35) | 645(45) | 83(58) | 265(38) | 463(53) | ||||
| >60 | 380(30) | 30(10) | 373(26) | 37(26) | 166(24) | 244(28) | ||||
| Race | AA | 319(25) | 102(33) | 0.002 | 380(27) | 41(29) | 0.101 | 239(34) | 182(21) | < .0001 |
| CA | 818(65) | 163(53) | 901(63) | 80(56) | 385(55) | 596(68) | ||||
| Asian | 48(4) | 16(5) | 58(4) | 6(4) | 26(4) | 38(4) | ||||
| Other | 77(6) | 27(9) | 88(6) | 16(11) | 45(6) | 59(7) | ||||
| Current OC use | No | 1189(94) | 262(85) | < .0001 | 1311(92) | 140(98) | 0.007⌂ | 613(88) | 838(96) | < .0001 |
| Yes | 73(6) | 46(15) | 116(8) | 3(2) | 82(12) | 37(4) | ||||
| Number of live birth | 0 | 234(19) | 120(39) | < .0001 | 330(23) | 24(17) | 0.013 | 177(25) | 177(20) | 0.011 |
| 1–2 | 645(51) | 146(47) | 725(51) | 66(46) | 351(51) | 440(50) | ||||
| ≥3 | 383(30) | 42(14) | 372(26) | 53(37) | 167(24) | 258(29) | ||||
| BMI | <25 | 576(46) | 180(58) | < .0001 | 691(48) | 65(45) | 0.498 | 307(44) | 449(51) | 0.005 |
| ≥25 | 686(54) | 128(42) | 736(52) | 78(55) | 388(56) | 426(49) | ||||
| HRT | Never | 814(65) | 267(87) | < .0001 | 989(69) | 92(64) | 0.174⌂ | 514(74) | 567(65) | < .0001 |
| Estrogen | 181(14) | 16(5) | 176(12) | 21(15) | 84(12) | 113(13) | ||||
| Combo | 230(18) | 21(7) | 222(16) | 29(20) | 79(11) | 172(20) | ||||
| Other 2 | 37(3) | 4(1) | 40(3) | 1(1) | 18(3) | 23(3) | ||||
Note
1 cases with missing values in all 6 factors were not included
2 “HRT, Other” was not used for FAC model selection due to low count.
⌂ indicates P-values from Fisher exact test; all other P-values were from Chi-square test. Abbreviations: FA = Fibroadenoma; FAC = Fibroadenomatoid Change; FCC = Fibrocystic Changes; Num. = Number; Race, AA = African American, CA = Caucasian American; Current OC use = Current oral contraceptive use; BMI = Body Mass Index; HRT = Hormonal replacement therapy; Combo = Estrogen & Progesterone.