Table 1. Serological responses to antigens in LT69 vaccine immunized mice.
Anti-ESAT6 | Anti-Ag85B | Anti-HspX | |||||||
---|---|---|---|---|---|---|---|---|---|
IgG1 | IgG2c | IgG2c/IgG1 | IgG1 | IgG2c | IgG2c/IgG1 | IgG1 | IgG2c | IgG2c/IgG1 | |
PBS | - | - | - | - | - | - | - | - | - |
BCG | 2.00 | < 2 | - | < 2 | < 2 | - | < 2 | < 2 | - |
EAMM+MH | 4.25±0.71 | 4.33±0.79 | 1.01±0.03 | 3.66±0.52 | 2.00 | 0.56±0.09 | 3.88±0.57 | 0.56±0.09 | 0.62±0.1 |
LT69(2 μg) * | 3.40± 1.14 | 4.51±0.62 | 1.4±0.38 | 3.96±0.52 | 3.43±0.15 | 0.88±0.14 | 4.18±0.15 | 0.88±0.14 | 0.75±0.04 |
LT69(10μg) * | 4.48±0.67 | 4.41±0.60 | 0.95±0.07 | 4.10±0.25 | 3.13±0.62 | 0.77±0.19 | 4.56±0.52 | 0.77±0.19 | 0.67±0.04 |
LT69(50μg) * | 4.55±0.3 | 4.31±0.69 | 0.91±0.15 | 4.41±0.25 | 3.12±0.62 | 0.71±0.17 | 4.41±0.81 | 0.71±0.17 | 0.63±0.2 |
*P < 0.05, relative to PBS and BCG groups