Table 3. Main results of the pooled data for the NOS3 +894G>T polymorphism.
Subgroups | TT vs. GG | TT+GT vs. GG | TT vs. GT+GG | T vs. G | GT vs. GG | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Ph | I 2 (%) | OR (95% CI) | Ph | I 2 (%) | OR (95% CI) | Ph | I 2 (%) | OR (95% CI) | Ph | I 2 (%) | OR (95% CI) | Ph | I 2 (%) | ||
Total | 1.29 (0.95,1.75) | 0.372 | 6.9 | 1.03 (0.66,1.60) | 0.000 | 80.8 | 1.27 (0.96,1.68) | 0.639 | 0 | 1.05 (0.82,1.34) | 0.015 | 64.4 | 0.97 (0.59,1.59) | 0.000 | 82.8 | |
Ethnicity | ||||||||||||||||
Caucasians | 1.08 (0.76,1.54) | 0.699 | 0 | 0.96 (0.75,1.24) | 0.000 | 0 | 1.13 (0.82,1.56) | 0.514 | 0 | 1.02 (0.86,1.21) | 0.827 | 0 | 0.93 (0.71,1.21) | 0.625 | 0 | |
Non-Caucasians | 2.10 (1.14,3.88) | 0.534 | 0 | 1.09 (0.40,2.99) | 0.002 | 92.1 | 1.84 (1.02,3.33) | 0.953 | 0 | 1.11 (0.63,1.94) | 0.002 | 84.5 | 0.99 (0.33,2.99) | 0.000 | 92.9 | |
Type of migraine | ||||||||||||||||
MA | Total | 1.61 (1.12,2.31) | 0.700 | 0 | 1.10 (0.65,1.87) | 0.001 | 76.4 | 1.50 (1.08,2.09) | 0.782 | 0 | 1.18 (0.90,1.55) | 0.057 | 53.4 | 0.97 (0.52,1.79) | 0.000 | 79.8 |
Caucasians | 1.43 (0.94,2.17) | 0.665 | 0 | 1.11 (0.81,1.51) | 0.996 | 0 | 1.41, (0.98,2.04) | 0.450 | 0 | 1.17 (0.95,1.44) | 0.787 | 0 | 0.99 (0.71,1.39) | 0.775 | 0 | |
Non-Caucasians | 2.37 (1.12,4.99) | 0.656 | 0 | 1.07 (0.30,3.88) | 0.000 | 90.5 | 1.93 (0.94 3.97) | 0.866 | 0 | 1.11 (0.56,2.19) | 0.007 | 80.0 | 0.93 (0.21,4.02) | 0.000 | 91.6 | |
MO | Total | 1.06 (0.73,1.54) | 0.233 | 26.9 | 0.94 (0.64,1.39) | 0.012 | 65.7 | 1.10 (0.78, 1.55) | 0.390 | 4.1 | 0.97 (0.75,1.24) | 0.058 | 53.1 | 0.93 (0.61,1.42) | 0.008 | 68.3 |
Caucasians | 0.80 (0.51,1.27) | 0.408 | 0 | 0.84 (0.62,1.14) | 0.832 | 0 | 0.89 (0.59, 1.35) | 0.299 | 17.1 | 0.89 (0.71,1.10) | 0.624 | 0 | 0.86 (0.62,1.19) | 0.627 | 0 | |
Non-Caucasians | 1.90 (0.97,3.73) | 0.625 | 0 | 1.05 (0.46,2.394) | 0.001 | 85.3 | 1.81 (0.95, 3.47) | 0.973 | 0 | 1.09 (0.67,1.78) | 0.018 | 75.2 | 0.96 (0.39,2.35) | 0.001 | 86.4 |
MA: migraine with aura; MO: migraine without aura; OR: odds ratio; 95% CI: 95% confidence interval