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. 2015 Jun 22;10(6):e0130819. doi: 10.1371/journal.pone.0130819

Fig 10. Left, MB-stained whole mount of 50% defect treated with BMP4/HGF, 3 months post-operation.

Fig 10

A short cone of cartilage (arrow) regenerated from the proximal end of the fibula. No regeneration took place from the distal end. Right, MB-stained whole mount of 50% defect treated with BMP4/HGF in which short cones of cartilage regenerated from both the proximal and distal ends of the fibula (arrows). Both specimens illustrate a common phenomenon encountered after removal of 50% of the bone, namely that the remaining distal and/or proximal bone segments regress to create closer to a 70% gap.