Fig. 4.
Secondary structures of the picornavirus cre elements and their locations in the genome. (A) A simplified version of the enterovirus and rhinovirus RNA genome is shown on top. Open loops of the PV1, HRV2 and HRV14 cre elements (section 2.1.3) are shown in detail with G1 and A14 shown in blue and A5 and A6 that template VPgpUpU synthesis are shown in red. Only the upper part of the stem is shown. (B) A simplified version of the cardiovirus and aphthovirus RNA genomes is shown on top. The hepatovirus genome is the same except it lacks the L protein. The loops of the EMCV, FMDV, and HAV cre elements (section 2.1.3) are shown in detail and A5 and A6 that template VPgpUpU synthesis are shown in red.