Table 1. Characteristics of prostate cancer cell lines, PDX models and 3D organoids.
Drug screens | ||||
Genetic manipulation | ||||
2D culture cell lines | Heterogeneity | |||
Initiation efficiency | Amenable | High throughput | ||
Low | ||||
PDX models | Loss | |||
Low | ||||
3D organoids | Maintained | Low throughput | ||
High | Not amenable | |||
Maintained | ||||
Amenable | ||||
High throughput |