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. Author manuscript; available in PMC: 2016 Mar 19.
Published in final edited form as: Curr Opin Genet Dev. 2015 Mar 19;30:42–48. doi: 10.1016/j.gde.2015.02.007

Table 1. Characteristics of prostate cancer cell lines, PDX models and 3D organoids.

Drug screens
Genetic manipulation
2D culture cell lines Heterogeneity
Initiation efficiency Amenable High throughput
Low
PDX models Loss
Low
3D organoids Maintained Low throughput
High Not amenable
Maintained
Amenable
High throughput