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. Author manuscript; available in PMC: 2016 Mar 17.
Published in final edited form as: Oncogene. 2014 Dec 22;34(38):4964–4974. doi: 10.1038/onc.2014.420

Figure 2.

Figure 2

The MET promoter 5′ proximal to the transcriptional start contains putative PAX and ETS sites. (A) Sequence from the MET locus, including 297 bp 5′ upstream to the transcriptional start site (arrow), and 25 bp of 5′ UTR that includes a SMAD SBE site (48), MITF site (39, 40), and HES/NOTCH site (49). A PAX site is indicated −752 to −746 by a black box. Putative ETS sites are shown −241 to −236 on the reverse strand of the sequence (ETS/P (E1), box) and −85 to −79 (ETS (E2), underline). (B) Nomenclature and schematics of MET reporter constructs containing the promoter sequence shown in (A) driving the reporter gene lucifierase. Constructs contain wild-type PAX (P) and ETS (E1 and E2) sites as shown in A or the sites that are mutated shown schematically with an X.