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. 2015 Apr 4;17(4):891–901. doi: 10.1208/s12248-015-9753-5

Fig. 4.

Fig. 4

Effect of variability comparison evaluation schemes (I, II, and III) and the regulatory standard (δ) on the study power (σ WR = 0.1), n = 24. Scheme I pass if the UPPER limit of the 90% CI for σ WT/σ WR ≤ δ, Scheme II pass if the LOWER limit of the 90% CI for σ WT/σ WR ≤ δ, and Scheme III pass if the ESTIMATE, sWT/sWR, is ≤δ