Table II.
Alphabetical Listing of Abbreviations
| Term | Description | Term | Description |
|---|---|---|---|
| C g m | Maximum concentration reached in vitro | T l m 2 | Time maximum concentration or amount is reached in vivo for Case 2 = T g m |
| C g m 2rt | Maximum concentration reached in vitro for Case 2rt | T l m 3 | Time maximum concentration or amount is reached in vivo for Case 3 |
| C g m/C g p | Supersaturation ratio in vitro | T l p 1 | Time plateau concentration or amount is reached in vivo for Case 1 = T g p |
| C g p | Plateau concentration reached in vitro = solubility in vitro | T l p 2 | Time plateau concentration or amount is reached in vivo for Case 2 |
| C g s | Drug concentration in solution in vitro | T l p 2rc | Time plateau concentration or amount is reached in vivo for Case 2rc |
| C l m/C l p | Supersaturation ratio in vivo | T l p 2rt | Time plateau concentration or amount is reached in vivo for Case 2rt |
| C l m or C l m 1 | Maximum concentration reached in vivo for Case 1 = C g m | T l p 3 | Time plateau concentration or amount is reached in vivo for Case 3 |
| C l m 2 | Maximum concentration reached in vivo for Case 2 | T l r | Small intestinal transit time or residence time in vivo |
| C l m 3 | Maximum concentration reached in vivo for Case 3 = C g m | V g | In vitro dissolution volume |
| C l n | Drug concentration in vivo in the absence of absorption | V l | Small intestinal fluid volume in vivo dissolution volume |
| C l p | Plateau concentration reached in vivo = C g p | X g e | Amount of excess solid drug in vitro |
| C l s | Drug concentration in solution in vivo | X g o | Initial amount of solid drug in vitro |
| k a | First-order absorption rate constant | X g s | Amount of drug in solution in vitro |
| T g m | Time maximum concentration or amount is reached in vitro | X l a | Amount of drug absorbed in vivo |
| T g p | Time plateau concentration or amount is reached in vitro | X l e | Amount of excess solid drug available for dissolution in vivo |
| T g r | End of experiment in vitro | X l o | Initial amount of solid drug in vivo = dose |
| T l m 1 | Time maximum concentration or amount is reached in vivo for Case 1 = T g m | X l s | Amount of drug in solution during in vitro dissolution |
Parameters used to describe the model are systemically abbreviated. The first letter in each parameter is capitalized and represents the variable as shown in Table I (e.g., C for concentration). The second letter in each parameter is either a subscript g denoting in vitro or subscript l denoting in vivo. The third letter is lowercase and represents the referred condition. For example, a term often used is C g m, which translates to the maximum concentration reached in vitro. Sometimes there is an addition subscripted suffix included in the parameter (1, 2, 3, 2rc, or 2rt and i, ii, and iii). This refers to a specific type of case and case and its phase