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Binding Affinity of Anti-PD-1 Antibody MIH4 for Recombinant Human sPD-1 Proteins
| Ligand (on chip) | 2 M excess PDL-1 | k a (1/Ms) | k d (1/s) | K D, nM | Chi2 |
|---|---|---|---|---|---|
| hPD1(25-167)-His | No | 1.3E + 5 | 3.8E-4 | 2.8 | 0.16 |
| hPD1(25-167)-His | Yes | 1.2E + 05 | 3.4E-04 | 2.9 | 0.08 |
| hPD1(25-167)-3S-IG | No | 4.8E + 5 | 2.4E-4 | 0.5 | 0.14 |
Association constant (k a), dissociation constant (k d), and binding constant (K D) for monomeric (hPD1(25-167)-His) and dimeric (hPD1(25-167)-3S-IG) sPD-1 proteins. Chi2: Goodness of fit
