Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of elimination rate of released small molecule on its delivery to intracellular space at varying doses. Note: All other parameters besides small molecule elimination rate are kept constant, i.e., CLRES = 5 mL/day/Kg; Vd_SM = 0.6 L/Kg; KD = 0.8 nM; ksyn = 64 μg/mL/day; Vd_Ab = 40 mL/Kg; kint = 2.77 h−1; number of receptor copies = 80,000 per cell; 1000 T cells per mm3 of blood
