Fig. 3.

Serum iron, UIBC, and antibody concentration in female SD rats after multiple dosing. ABT-207, h5F9-AM8, and vehicle were applied once weekly for 4 weeks and animals were necropsied 24 h after final dosing. Serum iron levels and UIBC in ABT-207 and h5F9-AM8-treated rats (a, b). Antibody drug concentration levels of ABT-207 and h5F9.AM8 (c, d). Statistical analysis in Fig. 3a, b shows significant effect (*p < 0.05, **p < 0.01, and ***p < 0.001) from one-way ANOVA conducting Dunnett’s post-hoc test with 0 mg/kg/week group (vehicle) as baseline. Data is displayed in mean and error bars represent standard error of the mean (SEM)