Fig. 6.

Serum iron and UIBC of SD rats and cynomolgus monkeys treated with 14 doses of ABT-207 once weekly followed by a 12-week recovery period. SD rats and cynomolgus monkeys were treated with ABT-207 at doses of 0, 2, 8, 40, and 200 mg/kg (rats) and 0, 2, 8, 40, and 160 mg/kg (cynomolgus monkeys) for 14 weeks and subsequently kept under recovery phase for 12 weeks. Total recovery of serum iron and UIBC was seen after 12 weeks for rats (a, c) and cynomolgus monkeys (b, d). Statistical analysis shows significant effect (*p < 0.05, **p < 0.01, and ***p < 0.001) from one-way ANOVA conducting Dunnett’s post-hoc test with 0 mg/kg/week group (vehicle) as baseline. Data is displayed in mean and error bars represent standard error of the mean (SEM)